Item Type | Name |
Concept
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Hexanols
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Concept
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Amino Acid Sequence
|
Concept
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Anticonvulsants
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Concept
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Immunosuppressive Agents
|
Concept
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Long QT Syndrome
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Concept
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Estrenes
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Concept
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Genes, Dominant
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Concept
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Fluorescent Antibody Technique
|
Concept
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Magnesium
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Concept
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Molecular Sequence Data
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Concept
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HeLa Cells
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Concept
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Oocytes
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Concept
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Potassium Channels
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Concept
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Interleukin-6
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Concept
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Humans
|
Concept
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Immunization
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Concept
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CHO Cells
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Concept
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4-Aminopyridine
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Concept
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Ion Channel Gating
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Concept
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Mutagenesis, Site-Directed
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Concept
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Genes, Reporter
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Concept
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Evolution, Molecular
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Concept
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Phosphatidylinositol 4,5-Diphosphate
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Concept
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1-Butanol
|
Concept
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Receptor Protein-Tyrosine Kinases
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Concept
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Potassium Channel Blockers
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Concept
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Shaker Superfamily of Potassium Channels
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Concept
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Ether-A-Go-Go Potassium Channels
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Concept
|
Amino Acid Substitution
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Concept
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Potassium Channels, Inwardly Rectifying
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Concept
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Jervell-Lange Nielsen Syndrome
|
Concept
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Proline
|
Concept
|
HEK293 Cells
|
Concept
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Immunoprecipitation
|
Concept
|
Andersen Syndrome
|
Concept
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Zebrafish
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Concept
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beta-Alanine
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Concept
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KCNQ1 Potassium Channel
|
Concept
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Kv1.2 Potassium Channel
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Concept
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Organogenesis
|
Concept
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Shaw Potassium Channels
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Concept
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Induced Pluripotent Stem Cells
|
Concept
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Antibodies
|
Concept
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Lysine
|
Concept
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T-Lymphocytes
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Concept
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Potassium Channels, Voltage-Gated
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Concept
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Kv1.5 Potassium Channel
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Concept
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Shab Potassium Channels
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Academic Article
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Gating of shaker-type channels requires the flexibility of S6 caused by prolines.
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Academic Article
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Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels.
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Academic Article
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Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.
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Academic Article
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Role of the S6 C-terminus in KCNQ1 channel gating.
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Academic Article
|
A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol.
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Academic Article
|
Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.
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Academic Article
|
KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.
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Academic Article
|
Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1.
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Academic Article
|
The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.
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Academic Article
|
Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp.
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Academic Article
|
Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.
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Academic Article
|
Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel.
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Academic Article
|
The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.
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Academic Article
|
A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.
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Academic Article
|
Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels.
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Academic Article
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Molecular mechanism for depolarization-induced modulation of Kv channel closure.
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Academic Article
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The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.
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Academic Article
|
Properties of deactivation gating currents in Shaker channels.
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Academic Article
|
The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.
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Academic Article
|
Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.
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Academic Article
|
Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.
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Academic Article
|
Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.
|
Academic Article
|
Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.
|
Academic Article
|
Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.
|
Academic Article
|
Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.
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Academic Article
|
Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach.
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Academic Article
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Inverted allosteric coupling between activation and inactivation gates in K+ channels.
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Academic Article
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Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations.
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Academic Article
|
The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels.
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Academic Article
|
Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient.
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Academic Article
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Reply to Pisupati et al.: Evaluating single subunit counting data to find the correct stoichiometry.
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Academic Article
|
Molecular autopsy and subsequent functional analysis reveal de novo DSG2 mutation as cause of sudden death.
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Academic Article
|
Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity.
|
Academic Article
|
The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels.
|
Academic Article
|
Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population.
|
Concept
|
ERG1 Potassium Channel
|
Academic Article
|
Correction: Gubic et al. Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity. Cancers 2022, 14, 2595.
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Academic Article
|
Immunosuppressive effects of new thiophene-based KV1.3 inhibitors.
|